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Polynucleotides for Neck and Décolletage: Say Goodbye to Horizontal Wrinkles

Polynucleotides offer an advanced option to improve skin quality in the neck and décolletage, reducing horizontal wrinkles and promoting natural collagen production.

September 27, 2026
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What are Polynucleotides and how do they work?

Polynucleotides are natural molecules derived from DNA, recognized for their ability to stimulate cell regeneration. When injected into the skin, they act on fibroblasts, the cells responsible for producing collagen and elastin. This process contributes to a progressive improvement in skin elasticity, hydration, and firmness.

This treatment does not seek an immediate volumetric change, but rather promotes the natural biostimulation of the skin. Its action focuses on repairing tissue at a cellular level, improving skin structure from within. Results are appreciated gradually, offering a rejuvenated and healthy appearance.

Why choose Polynucleotides for the neck and décolletage?

The skin of the neck and décolletage is particularly delicate and prone to showing signs of aging, such as horizontal wrinkles, sagging, and dehydration. Polynucleotides are an effective option for these areas, as they help improve skin quality without adding volume. They help reduce fine lines and restore radiance.

This treatment is suitable for those seeking a discreet and natural improvement, avoiding artificial results. Its safety profile and its ability to integrate with other aesthetic treatments make it a versatile option. Dr. Sol Monsalve, Medical Director of Santé Clínica Estética, emphasizes the importance of a medical approach for these delicate areas.

What is the procedure like at Santé Clínica Estética?

At Santé Clínica Estética, every polynucleotide treatment begins with a detailed medical consultation. Our board-certified doctors evaluate your skin condition and your expectations to design a personalized protocol. The procedure consists of microinjections of the polynucleotide solution into the treatment areas of the neck and décolletage.

It is an outpatient treatment that allows you to resume your usual activities immediately. A cycle of sessions is recommended to optimize results.

  graph TD
    A[Initial Medical Consultation] --> B{Skin Assessment & Personalized Protocol}
    B --> C[Polynucleotide Microinjections]
    C --> D[Post-Treatment Care Instructions]
    D --> E[Follow-up & Session Cycle Planning]

Results and expected timeline

The effects of polynucleotides develop gradually, as the skin stimulates its own collagen production. Results are progressively appreciated over the weeks and months following treatment, with an improvement in skin texture and firmness. Individual results may vary.

“Cellular regeneration is a process that takes time. With polynucleotides, we observe a sustained improvement in skin quality after completing the initial cycle of sessions.” – Dr. Sofía Generali, Aesthetic Doctor at Santé Clínica Estética.

Post-treatment care and contraindications

After polynucleotide injections, it is normal to experience slight redness, swelling, or small bruises in the treated areas, which usually disappear within a few days. It is recommended to avoid direct sun exposure and the use of makeup for the first 24 hours. It is also advisable not to engage in intense physical exercise on the day of treatment.

Although it is a safe treatment, there are some contraindications. It is not recommended for pregnant or breastfeeding women, people with active skin infections in the treatment area, or with severe autoimmune diseases. During the initial consultation, our medical team will review your medical history to ensure that the treatment is suitable for you.

Key points

  • Polynucleotides stimulate the natural production of collagen and elastin.
  • They help improve skin firmness, hydration, and radiance in the neck and décolletage.
  • Results are gradual and natural, without adding volume.
  • Several sessions are required to optimize benefits.
  • It is a medical procedure performed by qualified professionals.

How does Santé Clínica Estética approach this?

At Santé Clínica Estética, your well-being and the naturalness of the results are our priority. Our team of board-certified doctors, led by Dr. Sol Monsalve, conducts a thorough medical assessment before any treatment. This allows us to design a personalized protocol tailored to the unique characteristics of your skin and your aesthetic goals.

We use the most advanced techniques for polynucleotide application, ensuring maximum safety and efficacy. We understand that each patient is unique, which is why we offer a free aesthetic consultation where you can resolve all your doubts. Our team will assist you in Spanish, English, Portuguese, or Russian, ensuring clear and fluid communication throughout the process.

Polynucleotide treatment prices

Treatment Area Price per Session
Facial polynucleotides 400 €
Under-eye polynucleotides 400 €
Neck polynucleotides 400 €
Décolletage polynucleotides 400 €

Frequently asked questions

Is polynucleotide treatment painful?

Generally, the treatment is well tolerated. Methods can be used to minimize any discomfort. Some patients may feel a slight pricking sensation or pressure.

How long do the effects of polynucleotides last?

The effects can vary depending on the individual and their lifestyle. Maintenance sessions are recommended to prolong the results.

Can I combine polynucleotides with other aesthetic treatments?

Yes, polynucleotides can be combined with other treatments such as hyaluronic acid, neuromodulators, or radiofrequency, under the supervision of our medical team. Combining treatments allows for a comprehensive approach to different aspects of skin aging.

When will I see the final results?

The final results are appreciated progressively, as they depend on your skin's ability to generate new collagen and elastin.

Generalitat de Catalunya - Departament de Salut - Direcció General d'Ordenació i Regulació SanitàriaFinanciado por la Unión Europea - NextGenerationEU, Gobierno de España, ENISA, Plan de Recuperación, Transformación y Resiliencia