EZ Gel: The Next-Generation Plasma Gel with PRF for More Lasting Results

EZ Gel: when plasma gel evolves

Plasma gel marked a milestone in autologous aesthetic medicine by offering, for the first time, a viscoelastic filler 100% derived from the patient's own body. But research into bioplasmas didn't stop there. EZ Gel represents the next evolution: a plasma gel preparation system that incorporates a high-concentration fraction of platelet-rich fibrin (PRF), maximizing the content of growth factors and prolonging their release into the tissue.

If conventional plasma gel was already superior to hyaluronic acid in terms of biocompatibility and regenerative effect, EZ Gel amplifies that advantage.

How EZ Gel works: the role of PRF

PRF (Platelet-Rich Fibrin) differs from conventional PRP in a fundamental aspect: it does not require anticoagulants for its preparation. This means that fibrin — the protein that forms the clotting network — remains intact and polymerizes naturally, creating a three-dimensional fibrin matrix that traps platelets, leukocytes, and growth factors.

This fibrin matrix acts as a slow-release reservoir: growth factors are not released all at once into the tissue (as with standard PRP) but gradually over days and weeks. The regenerative effect is more sustained and, generally, more powerful.

EZ Gel combines:

1. Plasma gel (base): the viscoelastic gel obtained by thermal activation of plasma, which provides the volumizing effect and injectable consistency
2. Liquid or solid PRF: incorporated into the plasma gel preparation or injected into the same area sequentially

The result is an autologous biorefill with:

• Higher concentration of growth factors than standard plasma gel
• More prolonged release of factors (depot effect of fibrin)
• Greater tissue regenerative capacity (more activated fibroblasts, more new collagen)
• More potent anti-inflammatory effect

Differences between plasma gel, PRF, and EZ Gel

| | Plasma gel | PRF | EZ Gel |

|---|---|---|---|

| Base | Thermally activated plasma | Autologous fibrin | Plasma gel + PRF |

| Filling effect | High | Low-moderate | High |

| Growth factors | Moderate | High | Very high |

| GF release | Immediate-rapid | Slow (days-weeks) | Slow and prolonged |

| Result duration | 9-15 months | Variable (shorter) | 12-18 months estimated |

| Regenerative effect | Good | Very good | Excellent |

Indications for EZ Gel at Santé

EZ Gel is especially indicated when:

• The goal is to maximize the regenerative effect in addition to the volumizing one (patients with significant tissue quality loss in addition to volume)
• Patients over 45-50 years old with more marked tissue quality loss
• Areas that respond particularly well to growth factors: periocular, deep wrinkles, neck, hands
• Sun-damaged skin in need of tissue regeneration
• Patients seeking longer-lasting results compared to standard plasma gel
• As a post-treatment complement to more aggressive treatments (laser, HIFU) to enhance regeneration

The procedure at Santé

Preparation

Blood extraction follows the same protocol as plasma gel, with some differences in the centrifugation protocol to maximize the fibrin fraction:

1. Extraction of 2-4 blood tubes
2. Double-cycle centrifugation: first centrifugation to separate plasma, second to concentrate PRF
3. Thermal activation of plasma (75-85°C) to obtain the base gel
4. Preparation and, if applicable, incorporation of hot liquid PRF into the plasma gel

Application

Injection is performed with a cannula or fine needle depending on the area. The resulting gel has a slightly higher viscosity than standard plasma gel, which favors its persistence in the tissue.

The complete session (extraction + preparation + injection) lasts between 60 and 90 minutes.

Post-treatment

Similar to plasma gel: possible edema and hematomas within 48-72 hours. The medical team provides specific post-treatment instructions. Photoprotection is recommended for treated areas exposed to the sun.

Results: what to expect

• Immediate: visible volume correction (gel effect)
• 2-4 weeks: onset of tissue quality improvement due to growth factors
• 2-4 months: consolidation of the regenerative effect — firmer, denser skin, improved texture
• Estimated duration: 12-18 months (superior to standard plasma gel thanks to the fibrin reservoir)

Results vary depending on the patient's skin type, the treated area, and the exact protocol used. The doctor sets realistic expectations based on the prior assessment.

The learning curve: why Santé

The preparation of EZ Gel requires technical mastery of two distinct processes: the thermal activation of plasma gel and the preparation of PRF at the correct moment before its complete polymerization. The time window for working with liquid PRF is narrow — once the fibrin polymerizes completely, the resulting gel is not injectable.

The Santé team has extensive experience in bioplasmas (plasma gel, PRF, PRP), which ensures that EZ Gel is prepared with optimal properties in each session.

Frequently Asked Questions

How does EZ Gel differ from the plasma gel already offered at other clinics?

EZ Gel incorporates a high-concentration PRF fraction that standard plasma gel does not. This maximizes the growth factor content and prolongs their release, resulting in a superior regenerative effect.

Do I need more blood draws?

Yes, slightly more than for standard plasma gel, as tubes are needed for the dual preparation. The volume remains small and comparable to a typical clinical analysis.

Can I combine EZ Gel with other treatments in the same session?

Generally, it is not recommended to combine with very aggressive treatments on the same day. The doctor designs the protocol taking into account the order and interval between treatments.

How many sessions are recommended?

Usually 2-3 sessions for the initial cycle, spaced 4-6 weeks apart. Afterwards, annual maintenance or as evolution dictates.