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Lipolytic Enzymes: Non-Surgical Facial and Body Reshaping

Lipolytic enzymes are substances that, through microinjections, help reduce localized fat deposits in facial and body areas.

September 27, 2026
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What are lipolytic enzymes and how do they work?

Lipolytic enzymes are proteins that our body naturally produces and that participate in fat metabolism. In aesthetic medicine, we use synthetic or purified versions of these enzymes, such as lipase or collagenase, to selectively dissolve localized fat deposits.

Administered via precise microinjections directly into the adipose tissue, these enzymes work by fragmenting fat cells. Once fragmented, these fats are naturally eliminated by the body's lymphatic and circulatory system. The process is gradual and requires several sessions to observe optimal results.

This treatment is indicated for reducing fat accumulations that do not respond to diet or exercise. It is important to note that it is not a method for generalized weight loss, but rather for reshaping specific areas.

Who are lipolytic enzymes indicated for?

Lipolytic enzymes are an option for adults who have localized fat in specific areas of the body or face. They are especially suitable for people with relatively stable weight who are looking to define contours.

Common application areas include the double chin, flanks, abdomen, inner thighs, or arms. An initial medical evaluation is essential to determine if this treatment is the most suitable for your particular case.

Ideal candidates:

  • People with localized fat deposits resistant to diet and exercise.
  • Individuals seeking an improvement in body or facial contour without surgery.
  • Those with realistic expectations about treatment results.
  • Patients who are in good general health and have no contraindications.

What is the procedure like at Santé Clínica Estética?

At Santé Clínica Estética, each lipolytic enzyme treatment begins with a detailed medical consultation. Our board-certified doctors will evaluate your medical history and the areas to be treated to design a personalized plan.

On the day of the treatment, the area is cleaned and disinfected. Then, the doctor performs microinjections with a very fine needle, depositing the enzymes directly into the fatty tissue. The duration of the session varies according to the extent of the area, but usually lasts 30 to 60 minutes.

After the session, you may experience redness, swelling, or small bruises in the treated area. These reactions are temporary and usually disappear within a few days. It is recommended to avoid direct sun exposure and intense exercise for the first 24-48 hours.

Results and timeline

The results of lipolytic enzymes are not immediate, as the body needs time to process and eliminate fat. Generally, the first improvements are noticeable from the third or fourth week post-treatment.

The number of sessions needed varies depending on the amount of fat, the area to be treated, and the individual response of each patient. Typically, 3 to 6 sessions are recommended, spaced every 2 to 4 weeks. The final evaluation of the result is performed a few months after the last session.

Individual results may vary. The effectiveness of lipolytic enzymes for localized fat reduction has been observed in clinical practice, showing improvements in contour definition in selected patients after a multi-session protocol.

Typical treatment timeline:

Phase Activity Duration / Frequency
1. Initial Consultation Medical evaluation and plan design 1 session
2. Treatment Sessions Microinjections of lipolytic enzymes Every 2-4 weeks (3-6 sessions)
3. Post-session Recovery Reduction of swelling and bruising 3-7 days after each session
4. Onset of Results First visible improvements 3-4 weeks after the first session
5. Optimal Results Final contour evaluation 2-3 months after the last session
flowchart TD
    A[Initial Medical Consultation] --> B{Evaluation of Areas to Treat}
    B --> C[Personalized Treatment Plan Design]
    C --> D[Treatment Session 1: Microinjections]
    D --> E[Post-Session Recovery]
    E --> F{Repeat Sessions?}
    F -- Yes --> D
    F -- No --> G[Final Results Evaluation]

Possible side effects and contraindications

Like any medical procedure, lipolytic enzymes can have side effects, although they are usually mild and temporary. The most common include swelling, redness, tenderness, small bruises, or an itching sensation in the treated area. These symptoms usually subside within a few days.

It is essential to discuss any concerns with your doctor during the consultation. Contraindications include pregnancy, breastfeeding, active autoimmune diseases, infections in the treatment area, clotting problems, or allergy to any of the components.

How Santé Clinics approaches it

At Santé Clínica Estética, patient safety and satisfaction are our priority. All lipolytic enzyme treatments are performed by our board-certified doctors, who have extensive experience in aesthetic medicine and body reshaping.

Our approach focuses on a comprehensive medical evaluation for each patient. This allows us to design a personalized protocol that fits their needs and expectations, ensuring maximum efficacy and safety. We use products of the highest quality, approved for aesthetic medical use.

We offer a free initial aesthetic consultation to evaluate your case and answer all your questions. Our multilingual team will assist you in Spanish, English, Portuguese, or Russian, ensuring clear and comfortable communication. At Santé, we are committed to natural results that enhance your beauty subtly and harmoniously.

Key points

  • Lipolytic enzymes reduce localized fat through microinjections.
  • It is not a weight loss treatment, but for contour reshaping.
  • Requires multiple sessions (3-6) spaced every 2-4 weeks.
  • Results are gradual and noticeable from 3-4 weeks.
  • Medical evaluation and application by a board-certified doctor are essential.
  • Mild and temporary side effects: swelling, redness, bruising.

Frequently asked questions

Is lipolytic enzyme treatment painful?

Most patients experience minimal discomfort during microinjections, similar to small pinpricks. Topical anesthetic or ice can be applied to reduce any discomfort during the procedure.

How long do the results last?

The results of lipolytic enzymes are long-lasting, as long as healthy lifestyle habits are maintained. Eliminated fat cells do not regenerate, but significant weight gain can cause remaining fat cells to expand.

Can lipolytic enzymes be combined with other treatments?

Yes, in many cases, lipolytic enzymes can be combined with other body or facial treatments, such as radiofrequency (INDIBA) or body mesotherapy, to optimize results and improve skin quality. Your doctor at Santé will design a comprehensive plan if necessary.

What should I do before and after treatment?

Before treatment, avoid taking anticoagulants (aspirin, ibuprofen) if not medically necessary, to minimize the risk of bruising. Afterward, avoid direct sun exposure, intense exercise, and vigorous massages in the treated area for the first 24-48 hours. Maintaining good hydration is also important.

Generalitat de Catalunya - Departament de Salut - Direcció General d'Ordenació i Regulació SanitàriaFinanciado por la Unión Europea - NextGenerationEU, Gobierno de España, ENISA, Plan de Recuperación, Transformación y Resiliencia