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Photobiodynamic Therapy for Acne: What It Is and When It's Indicated

Photobiodynamic therapy is an advanced acne treatment that combines a photosensitive substance with LED light to reduce inflammation, eliminate bacteria, and improve skin quality.

September 27, 2026
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What is photobiodynamic therapy for acne?

Photobiodynamic therapy is a dermatological treatment that uses a photosensitizing substance, typically aminolevulinic acid (ALA), and a specific LED light source to treat acne. This combination selectively acts on hyperactive sebaceous glands and P. acnes bacteria, which are responsible for acne inflammation and lesions.

The process begins with the topical application of the photosensitizing substance to the skin. This substance is preferentially absorbed by problematic cells, such as sebaceous glands and bacteria. Subsequently, the area is exposed to LED light, which activates the photosensitizing substance.

This activation generates free radicals that destroy bacteria and reduce the activity of the sebaceous glands, decreasing sebum production. Additionally, photobiodynamic therapy promotes cell regeneration and improves overall skin texture. It is a medical approach that seeks to restore skin balance.

When is photobiodynamic therapy indicated?

Photobiodynamic therapy is especially indicated for cases of moderate to severe acne, including inflammatory acne, cystic acne, and acne resistant to other treatments. It is also an excellent option for people who cannot or do not wish to take oral medication due to side effects or contraindications.

Our medical team evaluates your history and current skin condition to determine if this treatment is the most suitable. We consider the extent and type of lesions, as well as your expectations and lifestyle. Protocols are adapted to offer maximum safety and effectiveness.

It is used to reduce inflammation, decrease the amount of bacteria, control sebum production, and minimize the appearance of new lesions. In addition, it helps to improve the appearance of post-acne marks and skin texture. Results vary depending on the patient and the severity of the acne.

How does the in-clinic treatment work?

The photobiodynamic therapy procedure is carried out in several phases, always under medical supervision. First, a deep cleansing of the skin is performed to ensure maximum absorption of the photosensitizer. This step is crucial for the effectiveness of the treatment.

Next, the photosensitizing substance is applied evenly to the areas to be treated. It is left on for a specific period, which can vary between 30 minutes and several hours, depending on the protocol established by the doctor. During this time, it is important to avoid direct sun exposure.

Once the incubation time has passed, exposure to LED light proceeds. The duration of this exposure is also adjusted individually. During the light session, sensations of warmth or a slight itch may be felt, which are usually well tolerated. Afterwards, the substance is removed, and soothing and protective products are applied.

Key points

  • Bacterial reduction: Eliminates P. acnes bacteria that cause inflammatory acne.
  • Sebum control: Decreases the activity of sebaceous glands, reducing oil production.
  • Anti-inflammatory: Calms the skin and reduces redness and lesion size.
  • Texture improvement: Contributes to smoother, more even skin, attenuating superficial marks.
  • Non-invasive: It is a treatment without surgery or injections, with minimal recovery time.
  • Customizable: Doctors adjust the concentration of the photosensitizer and the light intensity.

How Santé Clinics approaches it

At Santé Clinics, we understand that acne is a concern that requires a rigorous and personalized medical approach. Our team of board-certified doctors, with Dr. Sol Monsalve as Medical Director, evaluates each case individually to design the most effective photobiodynamic therapy protocol for you. We believe in evidence-based medicine and in offering solutions that respect the naturalness of your skin.

From the first consultation, which is free and without obligation, we analyze your skin type, the severity of your acne, and your goals. We ensure that you understand each step of the treatment and what to expect. Our commitment is your well-being and obtaining results that improve your quality of life safely and effectively. We use state-of-the-art medical devices to ensure precision and safety in each session.

In addition to photobiodynamic therapy, Santé Clinics offers a complementary range of acne treatments, such as Aquapure cleansing, specific chemical peels, or laser treatments like ClearLift, Q-Switched, or Erbium, which can be integrated into a comprehensive plan. Our goal is to address acne from multiple angles, ensuring complete care for your skin. We speak Spanish, English, Portuguese, and Russian.

Frequently asked questions

How many sessions are needed to see results?

The number of sessions varies depending on the severity of the acne and the individual response of each patient. Generally, 3 to 5 sessions are recommended, spaced every 2 to 4 weeks. Our medical team will provide you with a detailed treatment plan during your initial consultation.

Does photobiodynamic therapy have side effects?

Side effects are usually mild and temporary. They may include redness, swelling, flaking, or a slight burning sensation in the treated areas. These symptoms usually disappear within a few days. It is essential to rigorously protect yourself from the sun after treatment.

Is photobiodynamic therapy painful?

Most patients describe the treatment as tolerable. During light exposure, you may feel warmth or a slight itch. At Santé Clinics, we ensure you feel comfortable throughout the procedure and can apply measures to minimize any discomfort. Our medical team's experience is key in this aspect.

Can it be combined with other acne treatments?

Yes, photobiodynamic therapy can be effectively combined with other acne treatments, such as peels, mesotherapy, or laser treatments, under the supervision of our doctors. A combined approach can enhance results and address different aspects of acne. During your consultation, the most suitable plan for you will be discussed.

How much does a photobiodynamic therapy session cost?

A photobiodynamic (Photo-Biodynamic Peeling) session costs €180. This price is transparent, and you will be informed of any additional costs if other treatments are included in your personalized plan. The initial aesthetic consultation is free to assess your case.

Generalitat de Catalunya - Departament de Salut - Direcció General d'Ordenació i Regulació SanitàriaFinanciado por la Unión Europea - NextGenerationEU, Gobierno de España, ENISA, Plan de Recuperación, Transformación y Resiliencia