Table of Contents
- What are Polynucleotides and how do they work on the skin?
- Benefits of Polynucleotide Hydration
- Who are Polynucleotides indicated for?
- Application areas and treatment protocol
- What to expect during and after treatment?
- Key points
- Contraindications and safety
- How Santé Clínica Estética approaches it
- Frequently Asked Questions
What are Polynucleotides and how do they work on the skin?
Polynucleotides are natural biomolecules, specifically DNA fragments, used in aesthetic medicine to stimulate the regeneration and repair of skin tissues. When injected, they act at a cellular level, improving the skin's hydration, elasticity, and overall quality. Their mechanism of action focuses on activating the production of collagen and elastin, essential components for young and healthy skin.
This biostimulating treatment does not add volume; instead, it restores the skin's cellular function. It is an option for those looking to naturally improve skin texture, tone, and luminosity. Results are seen progressively as the skin regenerates from within.
Benefits of Polynucleotide Hydration
The application of polynucleotides offers multiple benefits for skin health and appearance. Their regenerative action helps combat signs of aging and improves tissue quality. This treatment is compatible with other aesthetic medicine techniques.
- Deep hydration: They improve the skin's ability to retain water, leading to long-lasting hydration.
- Improved elasticity and firmness: They stimulate the production of collagen and elastin, fundamental for skin structure.
- Reduction of fine lines and wrinkles: By regenerating tissue, they smooth superficial wrinkles and improve texture.
- Luminosity and even tone: They contribute to more radiant skin with a more homogeneous appearance.
- Repair and protection: They help repair cellular damage caused by external factors such as sun exposure.
Who are Polynucleotides indicated for?
Polynucleotides are suitable for a wide range of patients seeking to improve their skin quality. They are ideal for people who want to prevent aging or reverse its initial signs. This treatment is versatile and can be applied to various areas.
- Patients from 25-30 years old looking for preventive treatments.
- People with dehydrated, dull, or inelastic skin.
- Those with fine lines and mild wrinkles on the face, neck, or décolletage.
- Patients with dark circles and thin skin in the periocular area.
Application areas and treatment protocol
Polynucleotides can be applied to various areas where the skin requires regeneration and improvement. Common areas include the face, neck, décolletage, and eye contour.
The usual protocol typically consists of several sessions, spaced out over time, to optimize results. The number of sessions and frequency are determined during an individual medical assessment. Results consolidate over the weeks.
Table of Application Areas and Prices
| Application Area | Price per Session (€) | Pack of 3 Sessions (€) |
|---|---|---|
| Facial Polynucleotides | 400 | 1.000 |
| Under-Eye Polynucleotides | 400 | 1.000 |
| Neck Polynucleotides | 400 | - |
| Décolletage Polynucleotides | 400 | - |
What to expect during and after treatment?
The polynucleotide injection procedure is minimally invasive and generally well-tolerated. It is performed in the clinic and does not require significant downtime. It is important to follow the doctor's instructions to ensure optimal recovery.
Treatment Process
flowchart TD
A[Initial Medical Consultation] --> B(Skin Preparation)
B --> C{Polynucleotide Application}
C --> D[Immediate Post-treatment Care]
D --> E[Follow-up and Additional Sessions]
Post-treatment Considerations
Immediately after injections, it is normal to experience slight redness or swelling in the treated areas. These effects usually disappear within a few hours or days. It is recommended to avoid direct sun exposure and intense exercise for the first 24-48 hours. Results begin to be visible after 2-4 weeks and improve with each session.
“Cellular regeneration with polynucleotides is a gradual process. It is fundamental for patients to understand that the improvement in skin quality is built over time, by stimulating the body's natural functions.”
Key points
- Polynucleotides are DNA-based biostimulators that improve skin quality.
- They work by stimulating the natural production of collagen and elastin.
- They are ideal for deep hydration, elasticity, and the reduction of fine lines.
- They are applied to the face, neck, décolletage, and under-eye area.
- The protocol requires several sessions for optimal results.
- The price per facial or under-eye session is €400, with packs available.
Contraindications and safety
As with any medical treatment, there are some contraindications for the application of polynucleotides. A prior medical assessment is essential to guarantee patient safety. The medical team at Santé Clínica Estética performs a complete medical history before each procedure.
- Pregnancy and breastfeeding.
- Active infections in the treatment area.
- Severe autoimmune or systemic diseases.
- Known allergy to any of the components.
- Anticoagulant treatments (requires special assessment).
How Santé Clínica Estética approaches it
At Santé Clínica Estética, the application of polynucleotides is carried out under a strict medical protocol. Our team of board-certified doctors individually assesses each case to design a personalized treatment plan. We prioritize safety and natural results, in line with our philosophy of enhancing beauty without transforming it.
We offer a free aesthetic consultation where our specialists will answer all your questions and determine if this treatment is the most suitable for your needs. We speak Spanish, English, Portuguese, and Russian to facilitate communication. Our goal is to provide you with a comprehensive and trustworthy care experience.
Frequently Asked Questions
Are the results of polynucleotides immediate?
No, the results are not immediate as polynucleotides work by stimulating the skin's natural regenerative processes. Improvements in hydration, elasticity, and luminosity are observed progressively from 2-4 weeks after the first session, and continue to improve with the complete treatment cycle.
How many polynucleotide sessions do I need?
The number of sessions varies depending on the patient's age, the initial condition of the skin, and the area to be treated. Your doctor at Santé Clínica Estética will indicate the most suitable protocol during your personalized consultation.
Is polynucleotide treatment painful?
The treatment is performed using microinjections. Most patients describe mild and tolerable discomfort. For greater comfort, a topical anesthetic cream can be applied before the procedure. The needle used is very fine, which minimizes sensations.
Can I combine polynucleotides with other treatments?
Yes, polynucleotides are a very versatile treatment that can be combined with other aesthetic medicine techniques, such as hyaluronic acid fillers, neuromodulators, or laser treatments. Combining treatments can enhance results and address different skin concerns comprehensively. Your doctor will design the combined plan if necessary.
How long do the effects of polynucleotides last?
The duration of the effects of polynucleotides can vary individually. To prolong the results, your doctor will indicate the most suitable maintenance plan according to your needs.

