Polynucleotides for Under-Eye Circles: When Are They the Best Option?

Polynucleotides for under-eye circles: the alternative when filler is not indicated

The periorbital area, and under-eye circles in particular, is one of the facial areas that most concerns our patients. It is often directly associated with fatigue or aging. At Santé Clínica Estética, we understand the delicacy of this region and the importance of a precise medical approach. While hyaluronic acid filler is a known option for the under-eye hollow, it is not always the most suitable solution. This is where polynucleotides emerge as a valuable alternative, especially when the goal is to improve the intrinsic quality of the skin without adding volume.

What are polynucleotides and how do they work on under-eye circles?

Polynucleotides are natural molecules extracted from DNA, purified for use in aesthetic medicine. When injected into the skin, they act as biostimulators.

They promote cell regeneration, improve hydration, and stimulate the production of collagen and elastin. This results in firmer, more elastic, and luminous skin in the periorbital area.

Their mechanism of action is gradual, seeking an intrinsic improvement in dermal quality, not an immediate volume effect.

Filler or polynucleotides? The doctor's choice

The under-eye area is delicate and requires a precise medical evaluation. Traditionally, hyaluronic acid has been used to fill the hollow or groove of the under-eye circle. However, it is not always the optimal solution.

Sometimes, the patient's anatomy, the thin skin of the area, or the presence of fluid retention can make filler not the most indicated option. The risk of edema or an unnatural result is greater in these cases.

Polynucleotides are presented as a safe and effective alternative when the goal is to improve the quality of the under-eye skin. They do not provide volume, but rather revitalize and repair from within.

Main indications for polynucleotides in under-eye circles

• Under-eye circles with thin, dehydrated skin.
• Under-eye circles with mild to moderate pigmentation.
• Under-eye circles with signs of fatigue and loss of elasticity.
• Patients seeking a natural and progressive improvement, without a filler effect.
• As a complement to other treatments to optimize periorbital skin health.
• When hyaluronic acid filler is contraindicated or not desired.

The procedure at Santé Clínica Estética

At Santé, every treatment begins with a thorough medical consultation. Our doctors will assess your type of under-eye circle, your skin quality, and your expectations.

The polynucleotide injection procedure is minimally invasive. It is performed with very fine needles or cannulas, minimizing discomfort.

Several sessions are usually recommended to obtain optimal results, spaced over time. The final assessment of the results is made after completing the treatment cycle.

Polynucleotide treatment protocol

1. Free Medical Consultation
2. Personalized Evaluation
3. Area Preparation
4. Polynucleotide Injection
5. Immediate Post-treatment Care
6. Multiple Sessions (2-4 sessions, 2-4 weeks apart
7. Results Assessment
8. Maintenance (annual or biannual

Step	Description	Details
1. Medical Consultation	Personalized evaluation of the under-eye area and medical history.	Free at Santé Clínica Estética.
2. Preparation	Cleaning of the area and, if necessary, application of topical anesthesia.	Minimizes any discomfort.
3. Injection	Administration of polynucleotides through microinjections.	Performed by board-certified doctors.
4. Immediate Post-treatment	Brief massage and recommendations for home care.	Avoid rubbing the area.
5. Sessions	Generally 2-4 sessions, spaced 2-4 weeks apart.	The exact number is determined by the doctor.
6. Maintenance	Annual or biannual booster sessions, depending on individual response.	Results vary individually.

What results can I expect?

Polynucleotides work progressively. Do not expect an immediate change in volume, as their main action is biostimulation and improvement of skin quality.

Over time, you will notice more hydrated, elastic skin with a more even tone. The appearance of under-eye circles will be more rested and luminous. Results vary depending on each individual and the initial condition of the skin.

«The improvement in dermal density and elasticity after a cycle of polynucleotides can contribute to a more rested and luminous appearance in the under-eye area, always seeking a natural result and respecting individual physiognomy.»

It is essential to follow the doctor's instructions and complete the recommended protocol to maximize the benefits.

Key points

• Polynucleotides are biostimulators that improve the quality of under-eye skin.
• They do not provide volume, but rather promote hydration, elasticity, and cell regeneration.
• They are an excellent option when hyaluronic acid filler is not indicated.
• Treatment requires several sessions for optimal and progressive results.
• At Santé Clínica Estética, medical evaluation is fundamental for a personalized plan.

How Santé Clinics approaches it

At Santé Clínica Estética, safety and naturalness are our priority. Dr. Sol Monsalve, our Medical Director, supervises all protocols. For the treatment of under-eye circles with polynucleotides, our board-certified doctors perform a thorough evaluation of each patient.

We use high-quality products and precise injection techniques to ensure the best possible results. We understand that each face is unique, so your treatment plan will be completely personalized.

We offer a free aesthetic consultation where you can discuss your concerns and receive expert recommendations. Our multilingual team will assist you in Spanish, English, Portuguese, or Russian, ensuring clear and comfortable communication at our clinic at Avenida Diagonal 384, Barcelona.

Frequently asked questions

Do polynucleotides have side effects?

Side effects are usually mild and temporary, such as small bruises or swelling at the injection site. These disappear within a few days. Our doctors will provide you with all the instructions to minimize any discomfort.

How long do the effects of polynucleotides last?

The duration of the effects may vary, but generally they last between 6 and 12 months. To prolong the results, periodic maintenance sessions are recommended, which the doctor will plan according to your progress.

Can I combine polynucleotides with other treatments?

Yes, polynucleotides can be combined with other aesthetic treatments for the periorbital or facial area, such as mesotherapy, laser, or even, in some cases, small amounts of hyaluronic acid in other areas of the face. Always under the supervision and recommendation of our medical team to ensure compatibility and optimize results.

What is the price of polynucleotides for under-eye circles at Santé?

The price of polynucleotides for under-eye circles at Santé is €400 per session. We offer a pack of 3 sessions for €1,000, as several sessions are usually recommended to achieve the best results.