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May 2, 2026

Polynucleotide Injections for Tear Troughs: A Doctor's Guide

Understanding polynucleotide injections for tear trough hollows means exploring a gentle approach to under-eye rejuvenation. This guide explains how this treatment works, who it benefits, and what to expect during your journey.

Key point: Polynucleotides are natural compounds that encourage skin regeneration, offering a subtle approach to improving under-eye skin quality.

Key point: This treatment is distinct from traditional dermal fillers; it focuses on stimulating your skin's own repair mechanisms rather than simply adding volume.

Key point: A series of treatments is typically recommended to achieve optimal results, with gradual improvements in skin texture, elasticity, and hydration over several weeks.

Key point: Consultation with a medical professional is essential to determine if polynucleotide injections are the most suitable option for your specific under-eye concerns.

The area under our eyes, often referred to as the tear trough, can sometimes appear hollowed, shadowed, or show fine lines, contributing to a tired appearance. While various treatments address these concerns, polynucleotide injections offer a unique approach focused on improving skin quality and regeneration. At Santé Clínica Estética, we believe in providing clear, medically sound information to help you make informed decisions about your aesthetic journey.

Understanding Polynucleotide Injections

Polynucleotides are natural biostimulators derived from purified DNA fragments. When introduced into the skin, they work at a cellular level to stimulate fibroblasts, the cells responsible for producing collagen and elastin. This stimulation leads to improved skin elasticity, hydration, and overall texture. Unlike hyaluronic acid dermal fillers, which primarily add volume, polynucleotides aim to rejuvenate the skin from within, fostering a more natural and gradual improvement in the delicate under-eye area.

The science behind polynucleotides suggests their ability to promote tissue repair and reduce inflammation, making them a considered option for delicate areas like the tear trough. This approach is about encouraging your skin to function more optimally, leading to a refreshed appearance rather than an immediate 'filling' effect.

Who Can Benefit from Polynucleotide Injections for Tear Troughs?

Polynucleotide injections are generally considered for individuals who are beginning to notice signs of aging around the eyes or who have specific concerns about their under-eye skin quality. This may include:

  • Individuals with mild to moderate tear trough hollows who prefer a regenerative approach over volume addition.
  • Those experiencing thin, crepey skin under the eyes.
  • Patients looking to improve skin elasticity and hydration in the periorbital area.
  • Individuals seeking a natural, subtle improvement in their under-eye appearance.

It is important to note that polynucleotides may not be the primary solution for very deep hollows or significant volume loss, where traditional hyaluronic acid fillers might be more appropriate. A thorough consultation is always paramount to assess your specific needs and determine the most effective treatment plan.

What to Expect During and After the Procedure

The procedure typically involves a series of small injections directly into the skin of the tear trough area. Our medical professionals use fine needles to minimise discomfort. A topical anaesthetic cream may be applied beforehand to enhance your comfort during the treatment.

Realistic Timeline and Recovery

Typically, a course of 2-3 treatments is recommended, spaced 2-4 weeks apart, to achieve optimal results. The regenerative process stimulated by polynucleotides is gradual, meaning improvements in skin quality, texture, and hydration will become more apparent over several weeks following the initial treatment series. Individual results may vary based on skin condition and response to the treatment.

After the injections, you might experience some mild redness, swelling, or small bruises at the injection sites. These are generally temporary and tend to resolve within a few days. We advise avoiding strenuous exercise, excessive heat exposure (like saunas), and certain medications (such as blood thinners, if medically appropriate) for a short period post-treatment to minimise potential side effects. Most individuals can resume their normal activities shortly after the procedure.

Contraindications

While generally safe, polynucleotide injections are not suitable for everyone. Contraindications typically include pregnancy or breastfeeding, active skin infections in the treatment area, certain autoimmune diseases, or allergies to any components of the product. A detailed medical history will be taken during your consultation to ensure the treatment is safe and appropriate for you.

How Santé Clínica Estética Approaches This

At Santé Clínica Estética, your well-being and satisfaction are our priorities. Every treatment begins with a comprehensive, doctor-led consultation. During this session, our board-certified medical team will carefully assess your under-eye area, discuss your aesthetic goals, and review your medical history. We will explain the science behind polynucleotide injections, clarify what results can realistically be expected, and determine if this treatment aligns with your individual needs, or if another approach might be more beneficial.

Our commitment to a personalised protocol ensures that your treatment plan is tailored specifically to you. We offer complimentary consultations and our multilingual team is ready to assist you in Spanish, English, Portuguese, or Russian, ensuring clear communication and a comfortable experience from your first contact with us.

Frequently asked questions

How much do polynucleotide injections for tear troughs cost?

The cost of polynucleotide injections can vary depending on the number of sessions required and the specific product used. During your initial consultation at Santé Clínica Estética, we will provide a detailed breakdown of the treatment plan and associated costs, ensuring full transparency.

Are polynucleotide injections safe for the delicate under-eye area?

When administered by experienced medical professionals, polynucleotide injections are generally considered safe for the under-eye area. The products used are biocompatible and designed for delicate skin. As with any injectable treatment, there are potential side effects such as minor swelling or bruising, which are typically temporary.

How long do the results from polynucleotide injections last?

The results from polynucleotide injections are not permanent, as they work by stimulating your skin's natural processes. Following a complete course of treatments, improvements can typically last for several months. Maintenance sessions may be recommended to prolong the benefits, depending on individual skin response and lifestyle factors.

What is the difference between polynucleotides and hyaluronic acid fillers for tear troughs?

The primary difference lies in their mechanism of action. Hyaluronic acid fillers add immediate volume to fill hollows. Polynucleotides, on the other hand, stimulate the skin's own regenerative processes, improving skin quality, elasticity, and hydration over time without adding significant volume. Often, one treatment may complement the other, or one may be more suitable depending on the specific concern.

Financiado por la Unión Europea - NextGenerationEU, Gobierno de España, ENISA, Plan de Recuperación, Transformación y Resiliencia